By D. G. Cunningham Owens

ISBN-10: 0511005970

ISBN-13: 9780511005978

ISBN-10: 0521633532

ISBN-13: 9780521633536

Antipsychotic medications have revolutionized the administration of significant psychiatric problems and the results of these who are suffering from them. despite the fact that, they generally give a contribution to a number hostile results, one of the such a lot common and distressing of that are these leading to disturbance of voluntary motor functionality. Extrapyramidal facet effects--or EPS--are nonetheless poorly well-known and often misattributed. regardless of mammoth study literature, there were few makes an attempt to collect either the descriptive scientific parts of those problems and significant study conclusions pertinent to regimen perform. This very readable and well-illustrated ebook seeks to rectify this challenge within the wish of accelerating clinicians' expertise of the problems and acknowledgement in their influence. this can be a job made more difficult by way of the emergence of latest medicinal drugs with decrease legal responsibility which could advertise subtler abnormalities than commonplace compounds. This booklet can be a tremendous reference for psychiatrists, neurologists, and different clinicians who prescribe antipsychotic medicinal drugs.

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The most frequently implicated agent has been fluoxetine, but this probably reflects nothing more than this drug’s widespread use, particularly in the USA, from where most case reports have emanated. Fluvoxamine, paroxetine and even the early member of the group, trazodone, have also been implicated and it seems likely this is a group phenomenon. e. acute dystonias, parkinsonism, akathisia and dyskinesias. Some cases had received coincidental or prior antipsychotics, and it does appear that this may increase the likelihood of precipitating disorder.

Nonetheless, patients prescribed this compound should be monitored just as closely as those receiving antipsychotics. Antidepressants have hitherto remained remarkably untarnished, but this favourable appraisal now needs some revision, with possibly interesting ramifications. Tricyclics as a group may, in a small percentage of patients, produce a degree of excitement associated with restlessness and agitation – especially in the first few days of exposure – sometimes referred to as the ‘early tricyclic’ or ‘jitteriness’ syndrome (Pohl, Yeragani and Ortiz, 1986).

The literature does not, however, make anything of frank amputation. Nonetheless, in addition to the case noted, the author has been apprised of another example involving amputation of the 42 ACUTE DYSTONIAS anterior quarter, which also resulted in considerable disfigurement. Combining this with the relative frequency of trismus, one does wonder if such major trauma is more common than the literature would suggest. Both of the cases cited here were the subject of litigation, which may go some way to explaining a failure of material of this sort to reach publication.

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A Guide to the Extrapyramidal Side Effects of Antipsychotic Drugs by D. G. Cunningham Owens

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