By Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)
A awesome spectrum of novel immunoreceptors sharing similar immunoglobulin-like domain names and signaling power has been pointed out in recent times. those receptors have attracted common curiosity simply because they resemble the TCR, BCR, and FcR complexes of their skill to function activating or inhibitory receptors at the cells that undergo them. furthermore, they're good situated to impact either innate and adaptive immunity. the complete variety of ligands for those new receptor households continues to be no longer recognized, and realizing in their physiological roles is much from whole. This quantity is the 1st try and summarize and spotlight all identified points of immunoglobulin-like receptors, delivering a topical evaluate of the jobs and attribute positive factors of the immunoglobulin-like receptors and similar molecules within the immune process. Researchers in immunology, molecular biology, cellphone biology, medical drugs, and pharmacology will locate this e-book invaluable.
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Extra resources for Activating and Inhibitory Immunoglobulin-like Receptors
1997), decreased FcaR expression of circulating monocytes has recently been implicated in IgAN (Grossetete et al. 1998; Launay et al. 2000). In this context, a soluble form of FcaR has more recently been identified in IgAN patient serum as a putative pathogenic factor, and shown to be generated by proteolytic shedding in respon se to IgA (Launay et al. 2000) . Therefore, decreased FcaR expression on monocytes could result from the release of soluble FcaR from the cell surface. The FeaR promoter polymorph isms may be involved in one of the mech anism s underlying susceptibility to and/or pathogenesis of IgAN through increasing FeaR gene expre ssion , which might lead to increase soluble FeaR.
Clone 7 .... :. :. :. 3. :. ~'»l NKceli transcripts (C57BLl6) 1:-:-1·:·: ·1:-:-:· :1· :-:-:-: ·1· :I:-:·: ·f·: ·1-:-:1:·:·:-:-:1 Fig. 1. ' 1997). Two additional gp49A tran script s were found in NK cells but these contained intronic sequences. probably repre sentin g splicing intermediates. contain transmembrane charged residues that are utilized by ITIM -less KAR molecules to associate with signaling chains . The se dissimilarities indicate that mouse gp49 molecules are not true orthologs of human KIRIKAR .
Whereas CD94INKG2A orthologs are clearly present in both species (Ho et al. 1998; Lope z-Botet et al. 1997; Phillips et al. 1996; Vance et al. 1997), it is not yet clear if true orthologs of mouse Ly49 and human KIR exist in the reciprocal species. , MHC class I-specific receptors that inhibit NK cell activation. A human Ly49 gene has been isolated but it appears to be a pseudogene (Westgaard et at. 1998) and functional human Ly49 molecules have yet to be described . Conversely, mouse NK cells express Ig-Iike receptors.
Activating and Inhibitory Immunoglobulin-like Receptors by Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)