By Prof. Dr. Vladimir Veniaminovich Frolkis (auth.)
There is an Inca incantation which acknowledged acknowledged approximately: "Lord, supply me religious peace in order that i will acquiesce to what i can't switch, supply me braveness in order that i will swap what i will switch, and provides me knowledge in order that i will be able to distinguish one from the opposite. " evidently, this incantation may be frequently repeated by means of any gerontologist, because it is particularly tough to tell apart getting older from the approaches which counterpoint the organism's viability, getting older from illnesses, and the mechanisms of getting older in quite a few species of animals. in line with N. surprise, who compiled a worthwhile bibliography of the works on getting older, greater than 43,000 works on gerontology were released within the final decade. Why can we proceed to disagree with each other and carry that crucial mechanisms are nonetheless mostly unknown to us even with that movement of data and an incredible variety of evidence? what's it that we don't recognize? may perhaps or not it's that we don't comprehend the only real sacramental truth that may clarify every little thing, equivalent to the hormone of getting older, the programmed triggering of a suicide gene, the looks of a different poisonous agent within the axoplasmic move of gear, etc? Goethe as soon as wrote scientist normally holds convinced elements, yet regrettably he lacks their sacred link.
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Additional resources for Aging and Life-Prolonging Processes
It Table 1. Age changes in the brain neuronal population Brain structures Changes 0/0 Species Age Sex Reference Whole brain -70 Swiss albino mouse 1 vs. 29 months M,F Johnson, J. ; Miquel, J. (1974) Cerebral cortex -20 human 19-28 vs. 77 years M,F Shefer, V. F. (1972) Area 6 -22 human 19-28 vs. 77 years M,F Shefer, V. F. (1972) Subiculum -29 human 19-28 vs. 77 years M,F Shefer, V. F. (1972) Frontal polar region (area 10) -28 human 19-28 vs. 77 years M,F Shefer, V. F. (1972) Middle temporal gyrus (area 21) -23 human 19-28 vs.
28 months M Mezhiborskaya, N. A. (1971) no (- 2) rat 10-12 vs. 28 months M Mezhiborskaya, N. A. (1971) rat 1 vs. 28 months M Mezhiborskaya, N. A. (1971) no (-12) rat 6 vs. 28 months M Mezhiborskaya, N. A. (1971) no (- 4) rat 10-12 vs. 28 months M Mezhiborskaya, N. A. (1971) no human 0-90 years M,F Konigsmark, B. ; Murphy, E. A. (1970) Inferior olive nucleus no human Locus ceruleus -42 human Cerebellar cortex Lateral mammillary nucleus Perifomicate nucleus -18 Posterior hypothalamic nucleus Brain stem Ventral cochlear nucleus 7, 6 years Monagle, R.
F. (1972) Structural and Metabolic Changes in the Brain During Aging 37 Table 1 (continued) Brain structures Changes Species Age Sex Reference % Cerebral cortex (frontal pole, area striata, cingulate gyrus, precentral gyrus) Visual co rtex (area 17) Indusium griseum Colon, E. J. human to 90 years -24 Fischer 344 rat 11 vs. 29 months M Ordy, J. ; Brizzee, K. ; Hansche, J. (1978) -18 Fischer 344 rat 17 vs. 29 months M Ordy, J. ; Brizzee, K. ; Hansche, J. (1978) no (+8) ASH/TO mouse 5 vs. 18 months M Sturrock, R.
Aging and Life-Prolonging Processes by Prof. Dr. Vladimir Veniaminovich Frolkis (auth.)